Colchicoside

CNP0254965.2 · C27H33NO11 · View on COCONUT ↗

2D Structure

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Identifiers

Name	Colchicoside
IUPAC Name	~{N}-[(7~{S})-1,2,10-trimethoxy-9-oxo-3-[(2~{S},3~{R},4~{S},5~{S},6~{R})-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5~{H}-benzo[a]heptalen-7-yl]acetamide
COCONUT ID	CNP0254965.2
CAS	477-29-2, 1329-53-9
InChIKey	UXAFRQPVHYZDED-ZZEDUEFDSA-N
InChI	InChI=1S/C27H33NO11/c1-12(30)28-16-7-5-13-9-19(38-27-24(34)23(33)22(32)20(11-29)39-27)25(36-3)26(37-4)21(13)14-6-8-18(35-2)17(31)10-15(14)16/h6,8-10,16,20,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,20+,22+,23-,24+,27+/m0/s1
SMILES	COC1=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C2CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C3C2=C1OC

Properties

Molecular Formula	C27H33NO11
Molecular Weight	547.56
Exact Mass	547.20536
Log P (ALogP)	0.04
TPSA	173.24
H-Bond Donors / Acceptors	5 / 11
Rotatable Bonds	7
Lipinski's Rule of 5 Violations	2
QED Drug-likeness	0.32
NP-likeness	1.51

Classification

NP Pathway	Alkaloids
NP Superclass	Tyrosine alkaloids
NP Class	Phenethylisoquinoline alkaloids
Chemical Superclass	Hydrocarbon derivatives
Chemical Class	Tropones
Chemical Subclass	Tropones

Reported in GR-MAPs Plants

Gloriosa superba	as “Gloriosa superba” in COCONUT

References (7)

Data from COCONUT (COlleCtion of Open Natural prodUcTs), released under CC0. Chandrasekhar V. et al. COCONUT 2.0: a comprehensive overhaul and curation of the collection of open natural products database. Nucleic Acids Research (2024), doi:10.1093/nar/gkae1063. COCONUT release 2026-10.

COCONUT Compound